Vinblastine pharmacokinetics in mouse, dog, and human in the context of a physiologically based model incorporating tissue‐specific drug binding, transport, and metabolism

Vinblastine (VBL) is a vinca alkaloid‐class cytotoxic chemotherapeutic that causes microtubule disruption and is typically used to treat hematologic malignancies. VBL is characterized by a narrow therapeutic index, with key dose‐limiting toxicities being myelosuppression and neurotoxicity. Pharmacok...

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Detalles Bibliográficos
Autores principales: Witta, Sandra, Collins, Keagan P., Ramirez, Dominique A., Mannheimer, Joshua D., Wittenburg, Luke A., Gustafson, Daniel L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2023
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9834611/
https://www.ncbi.nlm.nih.gov/pubmed/36631976
http://dx.doi.org/10.1002/prp2.1052

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9834611/
https://www.ncbi.nlm.nih.gov/pubmed/36631976
http://dx.doi.org/10.1002/prp2.1052

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