Cargando…

CTP synthase 2 predicts inferior survival and mediates DNA damage response via interacting with BRCA1 in chronic lymphocytic leukemia

BACKGROUND: Cytidine triphosphate synthase 2 (CTPS2) is an essential metabolic enzyme that catalyzes the biosynthesis of CTP. CTP synthases contribute to lymphocytes proliferation and tumorigenesis, but the role of CTPS2 in chronic lymphocytic leukemia (CLL) remains undefined. METHODS: In silico ana...

Descripción completa

Detalles Bibliográficos
Autores principales:	Hu, Xinting, Han, Yang, Liu, Jiarui, Wang, Hua, Tian, Zheng, Zhang, Xin, Zhang, Ya, Wang, Xin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2023
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9835321/ https://www.ncbi.nlm.nih.gov/pubmed/36635772 http://dx.doi.org/10.1186/s40164-022-00364-0

Ejemplares similares

Nucleolar and spindle associated protein 1 enhances chemoresistance through DNA damage repair pathway in chronic lymphocytic leukemia by binding with RAD51
por: Han, Yang, et al.
Publicado: (2021)

CTP synthase: the hissing of the cellular serpent
por: Thangadurai, Shallinie, et al.
Publicado: (2022)

CTP synthase 1 deficiency in humans reveals its central role in lymphocyte proliferation
por: Martin, Emmanuel, et al.
Publicado: (2014)

The Interplay between Myc and CTP Synthase in Drosophila
por: Aughey, Gabriel N., et al.
Publicado: (2016)

Critical roles of CTP synthase N-terminal in cytoophidium assembly
por: Huang, Yong, et al.
Publicado: (2017)

The metabolic enzyme CTP synthase forms cytoskeletal filaments
por: Ingerson-Mahar, Michael, et al.
Publicado: (2010)

CTP Synthase Is Required for Optic Lobe Homeostasis in Drosophila
por: Tastan, Ömür Y., et al.
Publicado: (2015)

Forming cytoophidia prolongs the half-life of CTP synthase
por: Sun, Zhe, et al.
Publicado: (2019)

Structural basis for ligand binding modes of CTP synthase
por: Zhou, Xian, et al.
Publicado: (2021)

CTP synthase is essential for early endosperm development by regulating nuclei spacing
por: Yoon, Jinmi, et al.
Publicado: (2021)

Competing endogenous RNA networks related to prognosis in chronic lymphocytic leukemia: comprehensive analyses and construction of a novel risk score model
por: Zhang, Xin, et al.
Publicado: (2022)

CTP Synthase 1 Is a Novel Therapeutic Target in Lymphoma
por: Asnagli, Hélène, et al.
Publicado: (2023)

Only One Isoform of Drosophila melanogaster CTP Synthase Forms the Cytoophidium
por: Azzam, Ghows, et al.
Publicado: (2013)

Common regulatory control of CTP synthase enzyme activity and filament formation
por: Noree, Chalongrat, et al.
Publicado: (2014)

Human CTP synthase filament structure reveals the active enzyme conformation
por: Lynch, Eric M., et al.
Publicado: (2017)

A CTP Synthase Undergoing Stage-Specific Spatial Expression Is Essential for the Survival of the Intracellular Parasite Toxoplasma gondii
por: Narvaez-Ortiz, Heidy Y., et al.
Publicado: (2018)

CTP Synthase 2 From Arabidopsis thaliana Is Required for Complete Embryo Development
por: Hickl, Daniel, et al.
Publicado: (2021)

Diverged Early From CtpB and CtpC, CtpA Has Evolved to Process D1 Precursor in Oxygenic Photosynthetic Organisms
por: Chang, Weidong, et al.
Publicado: (2021)

CTP synthase polymerization in germline cells of the developing Drosophila egg supports egg production
por: Simonet, Jacqueline C., et al.
Publicado: (2020)

GTP-Dependent Regulation of CTP Synthase: Evolving Insights into Allosteric Activation and NH(3) Translocation
por: Bearne, Stephen L., et al.
Publicado: (2022)

Prognostic and Therapeutic Value of Apolipoprotein A and a New Risk Scoring System Based on Apolipoprotein A and Adenosine Deaminase in Chronic Lymphocytic Leukemia
por: Yun, Xiaoya, et al.
Publicado: (2021)

Ectopic miR-975 induces CTP synthase directed cell proliferation and differentiation in Drosophila melanogaster
por: Woo, Wai Kan, et al.
Publicado: (2019)

The Central Trigger Processor (CTP)
por: Franchini, Matteo
Publicado: (2016)

Leptogenesis: CTP, CPT & Flavour
por: Garbrecht, Bjoern
Publicado: (2011)

CTP Symposium on Supersymmetry at LHC
por: Khalil, Shaaban
Publicado: (2007)

Targeting metabolic reprogramming in chronic lymphocytic leukemia
por: Nie, Yu, et al.
Publicado: (2022)

dCTP Pyrophosphohydrase Exhibits Nucleic Accumulation in Multiple Carcinomas
por: Zhang, Y., et al.
Publicado: (2013)

RAD52 aptamer regulates DNA damage repair and STAT3 in BRCA1/BRCA2-deficient human acute myeloid leukemia
por: Xu, Yichuan, et al.
Publicado: (2020)

Human dCTP pyrophosphatase 1 promotes breast cancer cell growth and stemness through the modulation on 5-methyl-dCTP metabolism and global hypomethylation
por: Song, F-f, et al.
Publicado: (2015)

A metal‐dependent conformational change provides a structural basis for the inhibition of CTP synthase by gemcitabine‐5′‐triphosphate
por: McLeod, Matthew J., et al.
Publicado: (2023)

Diabetes Mellitus Is Associated with Inferior Prognosis in Patients with Chronic Lymphocytic Leukemia: A Propensity Score-Matched Analysis
por: Gao, Rui, et al.
Publicado: (2020)

Recent progress of prognostic biomarkers and risk scoring systems in chronic lymphocytic leukemia
por: Yun, Xiaoya, et al.
Publicado: (2020)

Accurate prediction of BRCA1 and BRCA2 heterozygous genotypes using expression profiling of lymphocytes after irradiation-induced DNA damage
por: Kote-Jarai, Z, et al.
Publicado: (2008)

The ALICE Central Trigger Processor (CTP) upgrade
por: Krivda, M, et al.
Publicado: (2016)

Cryo-EM structures of CTP synthase filaments reveal mechanism of pH-sensitive assembly during budding yeast starvation
por: Hansen, Jesse M, et al.
Publicado: (2021)

Crizotinib Shows Antibacterial Activity against Gram-Positive Bacteria by Reducing ATP Production and Targeting the CTP Synthase PyrG
por: Zheng, Yun-Dan, et al.
Publicado: (2022)

Improving but Inferior Survival in Patients with Chronic Lymphocytic Leukemia in Taiwan: A Population-Based Study, 1990–2004
por: Wu, Shang-Ju, et al.
Publicado: (2013)

BRCA1, BRCA2 and their possible function in DNA damage response
por: Kote-Jarai, Z, et al.
Publicado: (1999)

The ATLAS Level-1 Central Trigger Processor (CTP)
por: Ellis, Nick, et al.
Publicado: (2003)

The ATLAS Level-1 Central Trigger Processor (CTP)
por: Spiwoks, Ralf, et al.
Publicado: (2005)

Cannot write session to /tmp/vufind_sessions/sess_9kutvcilo3ldsbfr981dafgr5i