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Structure, mechanism and inhibition of anthranilate phosphoribosyltransferase

Anthranilate phosphoribosyltransferase catalyses the second reaction in the biosynthesis of tryptophan from chorismate in microorganisms and plants. The enzyme is homodimeric with the active site located in the hinge region between two domains. A range of structures in complex with the substrates, s...

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Detalles Bibliográficos
Autores principales: Scully, Thomas W., Jiao, Wanting, Mittelstädt, Gerd, Parker, Emily J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9835598/
https://www.ncbi.nlm.nih.gov/pubmed/36633281
http://dx.doi.org/10.1098/rstb.2022.0039