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Capturing the free energy of transition state stabilization: insights from the inhibition of mandelate racemase
Mandelate racemase (MR) catalyses the Mg(2+)-dependent interconversion of (R)- and (S)-mandelate. To effect catalysis, MR stabilizes the altered substrate in the transition state (TS) by approximately 26 kcal mol(–1) (–ΔG(tx)), such that the upper limit of the virtual dissociation constant of the en...
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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The Royal Society
2023
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9835602/ https://www.ncbi.nlm.nih.gov/pubmed/36633273 http://dx.doi.org/10.1098/rstb.2022.0041 |