Structural basis of mismatch recognition by a SARS-CoV-2 proofreading enzyme

Coronavirus 3′-to-5′ exoribonuclease (ExoN), residing in the nonstructural protein (nsp) 10–nsp14 complex, boosts replication fidelity by proofreading RNA synthesis and is critical for the virus life cycle. ExoN also recognizes and excises nucleotide analog inhibitors incorporated into the nascent R...

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Detalles Bibliográficos
Autores principales: Liu, Chang, Shi, Wei, Becker, Scott T., Schatz, David G., Liu, Bin, Yang, Yang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2021
Materias:
Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9836006/
https://www.ncbi.nlm.nih.gov/pubmed/34315827
http://dx.doi.org/10.1126/science.abi9310

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9836006/
https://www.ncbi.nlm.nih.gov/pubmed/34315827
http://dx.doi.org/10.1126/science.abi9310

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