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Pathological tau signatures and nuclear alterations in neurons, astrocytes and microglia in Alzheimer's disease, progressive supranuclear palsy, and dementia with Lewy bodies

Accumulation of pathological tau aggregates is a prominent feature in tauopathies that leads during the course of the diseases to neuronal dysfunction before and cell death after. Microglia and astrocytes have been described as playing important roles in synaptic spreading of toxic tau in several ne...

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Detalles Bibliográficos
Autores principales: Montalbano, Mauro, Majmundar, Lajja, Sengupta, Urmi, Fung, Leiana, Kayed, Rakez
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9836371/
https://www.ncbi.nlm.nih.gov/pubmed/36054524
http://dx.doi.org/10.1111/bpa.13112