Predictive modeling reveals that higher-order cooperativity drives transcriptional repression in a synthetic developmental enhancer

A challenge in quantitative biology is to predict output patterns of gene expression from knowledge of input transcription factor patterns and from the arrangement of binding sites for these transcription factors on regulatory DNA. We tested whether widespread thermodynamic models could be used to i...

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Detalles Bibliográficos
Autores principales: Kim, Yang Joon, Rhee, Kaitlin, Liu, Jonathan, Jeammet, Selene, Turner, Meghan A, Small, Stephen J, Garcia, Hernan G
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2022
Materias:
Physics of Living Systems
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9836395/
https://www.ncbi.nlm.nih.gov/pubmed/36503705
http://dx.doi.org/10.7554/eLife.73395

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9836395/
https://www.ncbi.nlm.nih.gov/pubmed/36503705
http://dx.doi.org/10.7554/eLife.73395

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