Cargando…
Predictive modeling reveals that higher-order cooperativity drives transcriptional repression in a synthetic developmental enhancer
A challenge in quantitative biology is to predict output patterns of gene expression from knowledge of input transcription factor patterns and from the arrangement of binding sites for these transcription factors on regulatory DNA. We tested whether widespread thermodynamic models could be used to i...
| Autores principales: | , , , , , , |
|---|---|
| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
eLife Sciences Publications, Ltd
2022
|
| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9836395/ https://www.ncbi.nlm.nih.gov/pubmed/36503705 http://dx.doi.org/10.7554/eLife.73395 |