Structural basis of transcription recognition of a hydrophobic unnatural base pair by T7 RNA polymerase

Bacteriophage T7 RNA polymerase (T7 RNAP) is widely used for synthesizing RNA molecules with synthetic modifications and unnatural base pairs (UBPs) for a variety of biotechnical and therapeutic applications. However, the molecular basis of transcription recognition of UBPs by T7 RNAP remains poorly...

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Detalles Bibliográficos
Autores principales: Oh, Juntaek, Kimoto, Michiko, Xu, Haoqing, Chong, Jenny, Hirao, Ichiro, Wang, Dong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9836923/
https://www.ncbi.nlm.nih.gov/pubmed/36635281
http://dx.doi.org/10.1038/s41467-022-35755-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9836923/
https://www.ncbi.nlm.nih.gov/pubmed/36635281
http://dx.doi.org/10.1038/s41467-022-35755-8

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