Oncogenic mutations of PIK3CA lead to increased membrane recruitment driven by reorientation of the ABD, p85 and C-terminus

PIK3CA encoding the phosphoinositide 3-kinase (PI3K) p110α catalytic subunit is frequently mutated in cancer, with mutations occurring widely throughout the primary sequence. The full set of mechanisms underlying how PI3Ks are activated by all oncogenic mutations on membranes are unclear. Using a sy...

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Detalles Bibliográficos
Autores principales: Jenkins, Meredith L., Ranga-Prasad, Harish, Parson, Matthew A. H., Harris, Noah J., Rathinaswamy, Manoj K., Burke, John E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9837058/
https://www.ncbi.nlm.nih.gov/pubmed/36635288
http://dx.doi.org/10.1038/s41467-023-35789-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9837058/
https://www.ncbi.nlm.nih.gov/pubmed/36635288
http://dx.doi.org/10.1038/s41467-023-35789-6

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