Modelling altered signalling of G-protein coupled receptors in inflamed environment to advance drug design

We previously reported the successful design, synthesis and testing of the prototype opioid painkiller NFEPP that does not elicit adverse side effects. The design process of NFEPP was based on mathematical modelling of extracellular interactions between G-protein coupled receptors (GPCRs) and ligand...

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Detalles Bibliográficos
Autores principales: Thies, Arne, Sunkara, Vikram, Ray, Sourav, Wulkow, Hanna, Celik, M. Özgür, Yergöz, Fatih, Schütte, Christof, Stein, Christoph, Weber, Marcus, Winkelmann, Stefanie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9837128/
https://www.ncbi.nlm.nih.gov/pubmed/36635362
http://dx.doi.org/10.1038/s41598-023-27699-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9837128/
https://www.ncbi.nlm.nih.gov/pubmed/36635362
http://dx.doi.org/10.1038/s41598-023-27699-w

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