Catalytic activities of a highly efficient cocaine hydrolase for hydrolysis of biologically active cocaine metabolites norcocaine and benzoylecgonine

Cocaine is a widely abused, hepatotoxic drug without an FDA-approved pharmacotherapy specific for cocaine addiction or overdose. It is recognized as a promising therapeutic strategy to accelerate cocaine metabolism which can convert cocaine to pharmacologically inactive metabolite(s) using an effici...

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Detalles Bibliográficos
Autores principales: Shang, Linyue, Jin, Zhenyu, Wei, Huimei, Park, Shawn, Zhan, Chang-Guo, Zheng, Fang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9837138/
https://www.ncbi.nlm.nih.gov/pubmed/36635293
http://dx.doi.org/10.1038/s41598-022-27280-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9837138/
https://www.ncbi.nlm.nih.gov/pubmed/36635293
http://dx.doi.org/10.1038/s41598-022-27280-x

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