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SLC27A5 promotes sorafenib-induced ferroptosis in hepatocellular carcinoma by downregulating glutathione reductase

Sorafenib, a first-line drug for advanced hepatocellular carcinoma (HCC), shows a favorable anti-tumor effect while resistance is a barrier impeding patients from benefiting from it. Thus, more efforts are needed to lift this restriction. Herein, we first find that solute carrier family 27 member 5...

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Detalles Bibliográficos
Autores principales: Xu, Feng-li, Wu, Xiao-hong, Chen, Chang, Wang, Kai, Huang, Lu-yi, Xia, Jie, Liu, Yi, Shan, Xue-feng, Tang, Ni
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9837139/
https://www.ncbi.nlm.nih.gov/pubmed/36635256
http://dx.doi.org/10.1038/s41419-023-05558-w