Mapping the determinants of catalysis and substrate specificity of the antibiotic resistance enzyme CTX-M β-lactamase

CTX-M β-lactamases are prevalent antibiotic resistance enzymes and are notable for their ability to rapidly hydrolyze the extended-spectrum cephalosporin, cefotaxime. We hypothesized that the active site sequence requirements of CTX-M-mediated hydrolysis differ between classes of β-lactam antibiotic...

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Detalles Bibliográficos
Autores principales: Judge, Allison, Hu, Liya, Sankaran, Banumathi, Van Riper, Justin, Venkataram Prasad, B. V., Palzkill, Timothy
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9837174/
https://www.ncbi.nlm.nih.gov/pubmed/36635385
http://dx.doi.org/10.1038/s42003-023-04422-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9837174/
https://www.ncbi.nlm.nih.gov/pubmed/36635385
http://dx.doi.org/10.1038/s42003-023-04422-z

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