Discovery of inhibitors against SARS-CoV-2 main protease using fragment-based drug design

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the etiological agent of coronavirus disease 2019 (COVID-19), in which the main protease (Mpro) plays an important role in the virus's life cycle. In this work, two representative peptide inhibitors (11a and PF-07321332) were selec...

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Detalles Bibliográficos
Autores principales: Shao, Hai Ping, Wang, Tian Hua, Zhai, Hong Lin, Bi, Ke Xin, Zhao, Bing Qiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier B.V. 2023
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9837207/
https://www.ncbi.nlm.nih.gov/pubmed/36642317
http://dx.doi.org/10.1016/j.cbi.2023.110352

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9837207/
https://www.ncbi.nlm.nih.gov/pubmed/36642317
http://dx.doi.org/10.1016/j.cbi.2023.110352

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