Kruppel-like factor 1–GATA1 fusion protein improves the sickle cell disease phenotype in mice both in vitro and in vivo

Sickle cell disease (SCD) and β-thalassemia are among the most common genetic disorders worldwide, affecting global health and mortality. Hemoglobin A2 (HbA2, α2δ2) is expressed at a low level in adult blood due to the lack of the Kruppel-like factor 1 (KLF1) binding motif in the δ-globin promoter r...

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Detalles Bibliográficos
Autores principales: Zhu, Jianqiong, Li, Hongzhen, Aerbajinai, Wulin, Kumkhaek, Chutima, Pirooznia, Mehdi, Saxena, Ankit, Dagur, Pradeep, Chin, Kyung, Rodgers, Griffin P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The American Society of Hematology 2022
Materias:
Regular Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9837447/
https://www.ncbi.nlm.nih.gov/pubmed/36399071
http://dx.doi.org/10.1182/blood.2021014877

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9837447/
https://www.ncbi.nlm.nih.gov/pubmed/36399071
http://dx.doi.org/10.1182/blood.2021014877

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