A Combined α-Synuclein/Fibril (SynFib) Model of Parkinson-Like Synucleinopathy Targeting the Nigrostriatal Dopamine System

Injections of pre-formed α-synuclein fibrils (PFFs) or overexpression of α-synuclein using AAV vectors are commonly used as models of Parkinson-like synucleinopathy in rats and mice. In the modified method reviewed here, the “SynFib” model, the PFFs and the AAV vector are administered together unila...

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Detalles Bibliográficos
Autores principales: Björklund, Anders, Nilsson, Fredrik, Mattsson, Bengt, Hoban, Deirdre B., Parmar, Malin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: IOS Press 2022
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9837691/
https://www.ncbi.nlm.nih.gov/pubmed/36189605
http://dx.doi.org/10.3233/JPD-223452

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9837691/
https://www.ncbi.nlm.nih.gov/pubmed/36189605
http://dx.doi.org/10.3233/JPD-223452

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