PRC2 disruption in cerebellar progenitors produces cerebellar hypoplasia and aberrant myoid differentiation without blocking medulloblastoma growth

We show that Polycomb Repressive Complex-2 (PRC2) components EED and EZH2 maintain neural identity in cerebellar granule neuron progenitors (CGNPs) and SHH-driven medulloblastoma, a cancer of CGNPs. Proliferating CGNPs and medulloblastoma cells inherit neural fate commitment through epigenetic mecha...

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Detalles Bibliográficos
Autores principales: Cleveland, Abigail H., Malawsky, Daniel, Churiwal, Mehal, Rodriguez, Claudia, Reed, Frances, Schniederjan, Matthew, Velazquez Vega, Jose E., Davis, Ian, Gershon, Timothy R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9838053/
https://www.ncbi.nlm.nih.gov/pubmed/36635771
http://dx.doi.org/10.1186/s40478-023-01508-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9838053/
https://www.ncbi.nlm.nih.gov/pubmed/36635771
http://dx.doi.org/10.1186/s40478-023-01508-x

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