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PRC2 disruption in cerebellar progenitors produces cerebellar hypoplasia and aberrant myoid differentiation without blocking medulloblastoma growth

We show that Polycomb Repressive Complex-2 (PRC2) components EED and EZH2 maintain neural identity in cerebellar granule neuron progenitors (CGNPs) and SHH-driven medulloblastoma, a cancer of CGNPs. Proliferating CGNPs and medulloblastoma cells inherit neural fate commitment through epigenetic mecha...

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Detalles Bibliográficos
Autores principales:	Cleveland, Abigail H., Malawsky, Daniel, Churiwal, Mehal, Rodriguez, Claudia, Reed, Frances, Schniederjan, Matthew, Velazquez Vega, Jose E., Davis, Ian, Gershon, Timothy R.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2023
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9838053/ https://www.ncbi.nlm.nih.gov/pubmed/36635771 http://dx.doi.org/10.1186/s40478-023-01508-x

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