Cargando…

UHPLC-ESI-QE-Orbitrap-MS based metabolomics reveals the antioxidant mechanism of icaritin on mice with cerebral ischemic reperfusion

BACKGROUND: Icaritin (ICT) has been previously demonstrated to display protective effects against cerebral ischemic reperfusion (I/R) by inhibiting oxidative stress, but the mechanism remains unclear. This study aimed to explore the mechanism from the perspective of metabolomics. METHODS: A mice cer...

Descripción completa

Detalles Bibliográficos
Autores principales:	Tang, Yunfeng, Sun, Lixin, Zhao, Yun, Yao, Jingchun, Feng, Zhong, Liu, Zhong, Zhang, Guimin, Sun, Chenghong
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	PeerJ Inc. 2023
Materias:	Biochemistry
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9838208/ https://www.ncbi.nlm.nih.gov/pubmed/36643627 http://dx.doi.org/10.7717/peerj.14483

Ejemplares similares

Chemical profiling analysis of Maca using UHPLC-ESI-Orbitrap MS coupled with UHPLC-ESI-QqQ MS and the neuroprotective study on its active ingredients
por: Zhou, Yanyan, et al.
Publicado: (2017)

Identification of Serum Metabolomics Characteristics in Patients with Stable Angina Pectoris Using UHPLC-QE-MS
por: Zhou, Yufei, et al.
Publicado: (2022)

Metabolomics Analysis of PK-15 Cells with Pseudorabies Virus Infection Based on UHPLC-QE-MS
por: Liu, Panrao, et al.
Publicado: (2022)

Retracted: Identification of Serum Metabolomics Characteristics in Patients with Stable Angina Pectoris Using UHPLC-QE-MS
por: Methods in Medicine, Computational and Mathematical
Publicado: (2023)

Study on the Material Basis of Houpo Wenzhong Decoction by HPLC Fingerprint, UHPLC-ESI-LTQ-Orbitrap-MS, and Network Pharmacology
por: Luo, Juyuan, et al.
Publicado: (2019)

Structural Characterization and Antioxidant Capacity of Quinoa Cultivars Using Techniques of FT-MIR and UHPLC/ESI-Orbitrap MS Spectroscopy
por: García-Parra, Miguel, et al.
Publicado: (2021)

Study of the Metabolic Profiles of “Indazole-3-Carboxamide” and “Isatin Acyl Hydrazone” (OXIZID) Synthetic Cannabinoids in a Human Liver Microsome Model Using UHPLC-QE Orbitrap MS
por: Xiang, Jiahong, et al.
Publicado: (2023)

Pharmacokinetics and Metabolism Research of Shenkang Injection in Rats Based on UHPLC-MS/MS and UHPLC-Q-Orbitrap HRMS
por: Jiang, Xiaofang, et al.
Publicado: (2020)

Investigating the Active Substance and Mechanism of San-Jiu-Wei-Tai Granules via UPLC-QE-Orbitrap-MS and Network Pharmacology
por: Yu, Gengyuan, et al.
Publicado: (2022)

UHPLC-ESI-Orbitrap-MS Analysis of Biologically Active Extracts from Gynura procumbens (Lour.) Merr. and Cleome gynandra L. Leaves
por: Chandradevan, Machap, et al.
Publicado: (2020)

Evaluation of female Aedes aegypti proteome via LC-ESI-MS/MS using two protein extraction methods
por: Shettima, Abubakar, et al.
Publicado: (2021)

LC-ESI/LTQ-Orbitrap-MS Based Metabolomics in Evaluation of Bitter Taste of Arbutus unedo Honey
por: Montoro, Paola, et al.
Publicado: (2021)

Insights into the metabolic profiling of Polygonati Rhizoma fermented by Lactiplantibacillus plantarum under aerobic and anaerobic conditions using a UHPLC-QE-MS/MS system
por: Wang, ZiLing, et al.
Publicado: (2023)

Nutritional Composition, Anti-Diabetic Properties and Identification of Active Compounds Using UHPLC-ESI-Orbitrap-MS/MS in Mangifera odorata L. Peel and Seed Kernel
por: Lasano, Nur Fatimah, et al.
Publicado: (2019)

Chemical Discrimination of Astragalus mongholicus and Astragalus membranaceus Based on Metabolomics Using UHPLC-ESI-Q-TOF-MS/MS Approach
por: Wang, Yumei, et al.
Publicado: (2019)

Evaluation of the Nutritional Quality of Chinese Kale (Brassica alboglabra Bailey) Using UHPLC-Quadrupole-Orbitrap MS/MS-Based Metabolomics
por: Wang, Ya-Qin, et al.
Publicado: (2017)

UHPLC-Q-Orbitrap-MS-Based Metabolomics Reveals Chemical Variations of Two Types of Rhizomes of Polygonatum sibiricum
por: Luo, Gelian, et al.
Publicado: (2022)

Simultaneous Determination of Structurally Diverse Compounds in Different Fangchi Species by UHPLC-DAD and UHPLC-ESI-MS/MS
por: Sim, Hee-Jung, et al.
Publicado: (2013)

Icaritin attenuates 6-OHDA-induced MN9D cell damage by inhibiting oxidative stress
por: Zhou, Xinyu, et al.
Publicado: (2022)

Chilean Rhubarb, Gunnera tinctoria (Molina) Mirb. (Gunneraceae): UHPLC-ESI-Orbitrap-MS Profiling of Aqueous Extract and its Anti-Helicobacter pylori Activity
por: Hebel-Gerber, Sonja, et al.
Publicado: (2021)

Authentication of milk thistle commercial products using UHPLC-QTOF-ESI + MS metabolomics and DNA metabarcoding
por: Raclariu-Manolică, Ancuța Cristina, et al.
Publicado: (2023)

UHPLC-ESI-MS/MS Quantitative Analyses of Multicomponent Hu Gan Tablets
por: Liang, Jun, et al.
Publicado: (2019)

Effect of icaritin on autophagy-related protein expression in TDP-43-transfected SH-SY5Y cells
por: Zhou, Yanjun, et al.
Publicado: (2022)

Screening of Quality Markers During the Processing of Reynoutria multiflora Based on the UHPLC-Q-Exactive Plus Orbitrap MS/MS Metabolomic Method
por: Bai, Junqi, et al.
Publicado: (2021)

Characterization of LC-MS based urine metabolomics in healthy children and adults
por: Liu, Xiaoyan, et al.
Publicado: (2022)

Rapid Discovery of the Potential Toxic Compounds in Polygonum multiflorum by UHPLC/Q-Orbitrap-MS-Based Metabolomics and Correlation Analysis
por: Han, Lifeng, et al.
Publicado: (2019)

Icaritin protects SH-SY5Y cells transfected with TDP-43 by alleviating mitochondrial damage and oxidative stress
por: Zhou, Yongjian, et al.
Publicado: (2021)

Study on Pharmacokinetics and Metabolic Profiles of Novel Potential PLK-1 Inhibitors by UHPLC-MS/MS Combined with UHPLC-Q-Orbitrap/HRMS
por: Wang, Lin, et al.
Publicado: (2023)

Secondary Metabolite Profiling of Species of the Genus Usnea by UHPLC-ESI-OT-MS-MS
por: Salgado, Francisco, et al.
Publicado: (2017)

Simultaneous Determination of Five Iridoids of Picrorhiza scrophulariiflora in Rat Plasma Using UHPLC-ESI-MS/MS
por: Wang, Zhibin, et al.
Publicado: (2023)

Antiseptic Activity of Ethnomedicinal Xuebijing Revealed by the Metabolomics Analysis Using UHPLC-Q-Orbitrap HRMS
por: Zuo, Lihua, et al.
Publicado: (2018)

Analysis of Chemical Constituents in Wuzi-Yanzong-Wan by UPLC-ESI-LTQ-Orbitrap-MS
por: Zou, Dixin, et al.
Publicado: (2015)

UHPLC-ESI-ORBITRAP-MS analysis of the native Mapuche medicinal plant palo negro (Leptocarpha rivularis DC. – Asteraceae) and evaluation of its antioxidant and cholinesterase inhibitory properties
por: Jiménez-González, Andrea, et al.
Publicado: (2018)

Integration of UHPLC/Q-OrbitrapMS-based metabolomics and activities evaluation to rapidly explore the anti-inflammatory components from lasianthus
por: Zhang, Lele, et al.
Publicado: (2023)

Analysis of isoquinoline alkaloids from Mahonia leschenaultia and Mahonia napaulensis roots using UHPLC-Orbitrap-MS(n) and UHPLC-QqQ(LIT)-MS/MS
por: Singh, Awantika, et al.
Publicado: (2017)

Identification of the metabolites of isochlorogenic acid A in rats by UHPLC-Q-Exactive Orbitrap MS
por: Gong, Kaiyan, et al.
Publicado: (2020)

UHPLC-Q-Exactive Orbitrap MS/MS-Based Untargeted Metabolomics and Molecular Networking Reveal the Differential Chemical Constituents of the Bulbs and Flowers of Fritillaria thunbergii
por: Li, Xin, et al.
Publicado: (2022)

Fast Simultaneous Determination of 13 Nucleosides and Nucleobases in Cordyceps sinensis by UHPLC–ESI–MS/MS
por: Zong, Shi-Yu, et al.
Publicado: (2015)

Uncovering the Dissipation of Chlorantraniliprole in Tomatoes: Identifying Transformation Products (TPs) and Coformulants in Greenhouse and Laboratory Studies by UHPLC-Q-Orbitrap-MS and GC-Q-Orbitrap-MS
por: Maldonado-Reina, Antonio Jesús, et al.
Publicado: (2023)

Characterization of in-vivo human metabolites of the oral nucleoside anti-COVID-19 drug VV116 using UHPLC-Orbitrap-MS
por: Zhou, Ainan, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_i2ba4sh3h55og7vpaii5grc485