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Investigation of gate-engineered heterostructure tunnel field effect transistor as a label-free biosensor: a compact study

In this article, the authors have articulated DC as well as transient response of a dielectric modulated gate-engineered heterostructure tunnel field effect transistor (GE-HTFET)-based biosensor for label-free detection. A low (direct) bandgap material, indium arsenide (InAs) has been selectively us...

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Autores principales: Ghosh, Rittik, Karmakar, Ananya, Saha, Priyanka
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9838274/
https://www.ncbi.nlm.nih.gov/pubmed/36683913
http://dx.doi.org/10.1007/s00339-023-06393-8
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author Ghosh, Rittik
Karmakar, Ananya
Saha, Priyanka
author_facet Ghosh, Rittik
Karmakar, Ananya
Saha, Priyanka
author_sort Ghosh, Rittik
collection PubMed
description In this article, the authors have articulated DC as well as transient response of a dielectric modulated gate-engineered heterostructure tunnel field effect transistor (GE-HTFET)-based biosensor for label-free detection. A low (direct) bandgap material, indium arsenide (InAs) has been selectively used in the source region to achieve improved band-to-band tunneling of carriers in the tunnel FET. The extended gate architecture is incorporated to stabilize the biomolecules in the nano-cavity aiding significant boost in ON current sensitivity. Using SILVACO ATLAS TCAD tool, the sensitivity of the biosensor is evaluated considering two important parameters possessed by bio-targets, i.e. dielectric constant (k) and charge density (N). A thorough analysis has been performed to show the impact of variation of dielectric constants and charge density of biomolecules over transfer characteristics of the device. ON current level (Ion) is eventually extracted which is considered here as the suitable sensing parameter of the device. Transient response to detect the settling time of Ion is also demonstrated here in presence of both positively and negatively charged bio-species with varying values of dielectric constant. Then ON current sensitivity is extracted accordingly for different locations of biomolecules within the nano-gap. Finally, an extensive comparative analysis of the present structure in terms of ON current sensitivity is shown to justify its sensing ability as compared to recently reported device structures.
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spelling pubmed-98382742023-01-17 Investigation of gate-engineered heterostructure tunnel field effect transistor as a label-free biosensor: a compact study Ghosh, Rittik Karmakar, Ananya Saha, Priyanka Appl Phys A Mater Sci Process Article In this article, the authors have articulated DC as well as transient response of a dielectric modulated gate-engineered heterostructure tunnel field effect transistor (GE-HTFET)-based biosensor for label-free detection. A low (direct) bandgap material, indium arsenide (InAs) has been selectively used in the source region to achieve improved band-to-band tunneling of carriers in the tunnel FET. The extended gate architecture is incorporated to stabilize the biomolecules in the nano-cavity aiding significant boost in ON current sensitivity. Using SILVACO ATLAS TCAD tool, the sensitivity of the biosensor is evaluated considering two important parameters possessed by bio-targets, i.e. dielectric constant (k) and charge density (N). A thorough analysis has been performed to show the impact of variation of dielectric constants and charge density of biomolecules over transfer characteristics of the device. ON current level (Ion) is eventually extracted which is considered here as the suitable sensing parameter of the device. Transient response to detect the settling time of Ion is also demonstrated here in presence of both positively and negatively charged bio-species with varying values of dielectric constant. Then ON current sensitivity is extracted accordingly for different locations of biomolecules within the nano-gap. Finally, an extensive comparative analysis of the present structure in terms of ON current sensitivity is shown to justify its sensing ability as compared to recently reported device structures. Springer Berlin Heidelberg 2023-01-10 2023 /pmc/articles/PMC9838274/ /pubmed/36683913 http://dx.doi.org/10.1007/s00339-023-06393-8 Text en © The Author(s), under exclusive licence to Springer-Verlag GmbH, DE part of Springer Nature 2023, Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law. This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.
spellingShingle Article
Ghosh, Rittik
Karmakar, Ananya
Saha, Priyanka
Investigation of gate-engineered heterostructure tunnel field effect transistor as a label-free biosensor: a compact study
title Investigation of gate-engineered heterostructure tunnel field effect transistor as a label-free biosensor: a compact study
title_full Investigation of gate-engineered heterostructure tunnel field effect transistor as a label-free biosensor: a compact study
title_fullStr Investigation of gate-engineered heterostructure tunnel field effect transistor as a label-free biosensor: a compact study
title_full_unstemmed Investigation of gate-engineered heterostructure tunnel field effect transistor as a label-free biosensor: a compact study
title_short Investigation of gate-engineered heterostructure tunnel field effect transistor as a label-free biosensor: a compact study
title_sort investigation of gate-engineered heterostructure tunnel field effect transistor as a label-free biosensor: a compact study
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9838274/
https://www.ncbi.nlm.nih.gov/pubmed/36683913
http://dx.doi.org/10.1007/s00339-023-06393-8
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