In silico investigation of falcipain-2 inhibition by hybrid benzimidazole-thiosemicarbazone antiplasmodial agents: A molecular docking, molecular dynamics simulation, and kinetics study

The emergence of artemisinin-resistant variants of Plasmodium falciparum necessitates the urgent search for novel antimalarial drugs. In this regard, an in silico study to screen antimalarial drug candidates from a series of benzimidazole-thiosemicarbazone hybrid molecules with interesting antiplasm...

Descripción completa

Detalles Bibliográficos
Autores principales: Nkungli, Nyiang Kennet, Fouegue, Aymard Didier Tamafo, Tasheh, Stanley Numbonui, Bine, Fritzgerald Kogge, Hassan, Abrar Ul, Ghogomu, Julius Numbonui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2023
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9838286/
https://www.ncbi.nlm.nih.gov/pubmed/36622482
http://dx.doi.org/10.1007/s11030-022-10594-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9838286/
https://www.ncbi.nlm.nih.gov/pubmed/36622482
http://dx.doi.org/10.1007/s11030-022-10594-3

Ejemplares similares