Tramadol regulates the activation of human platelets via Rac but not Rho/Rho-kinase

Tramadol is a useful analgesic which acts as a serotonin and noradrenaline reuptake inhibitor in addition to μ-opioid receptor agonist. Cytoplasmic serotonin modulates the small GTPase activity through serotonylation, which is closely related to the human platelet activation. We recently reported th...

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Detalles Bibliográficos
Autores principales: Iida, Hiroki, Onuma, Takashi, Nakashima, Daiki, Mizutani, Daisuke, Hori, Takamitsu, Ueda, Kyohei, Hioki, Tomoyuki, Kim, Woo, Enomoto, Yukiko, Doi, Tomoaki, Matsushima-Nishiwaki, Rie, Yamaguchi, Shinobu, Tachi, Junko, Tanabe, Kumiko, Ogura, Shinji, Iwama, Toru, Kozawa, Osamu, Tokuda, Haruhiko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9838859/
https://www.ncbi.nlm.nih.gov/pubmed/36638092
http://dx.doi.org/10.1371/journal.pone.0279011

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9838859/
https://www.ncbi.nlm.nih.gov/pubmed/36638092
http://dx.doi.org/10.1371/journal.pone.0279011

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