Protein structure prediction has reached the single-structure frontier

Dramatic advances in protein structure prediction have sparked debate as to whether the problem of predicting structure from sequence is solved or not. Here, I argue that AlphaFold2 and its peers are currently limited by the fact that they predict only a single structure, instead of a structural dis...

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Detalles Bibliográficos
Autor principal: Lane, Thomas J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group US 2023
Materias:
Comment
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9839224/
https://www.ncbi.nlm.nih.gov/pubmed/36639584
http://dx.doi.org/10.1038/s41592-022-01760-4
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author Lane, Thomas J.
author_facet Lane, Thomas J.
author_sort Lane, Thomas J.
collection PubMed
description Dramatic advances in protein structure prediction have sparked debate as to whether the problem of predicting structure from sequence is solved or not. Here, I argue that AlphaFold2 and its peers are currently limited by the fact that they predict only a single structure, instead of a structural distribution, and that this realization is crucial for the next generation of structure prediction algorithms.
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spelling pubmed-98392242023-01-17 Protein structure prediction has reached the single-structure frontier Lane, Thomas J. Nat Methods Comment Dramatic advances in protein structure prediction have sparked debate as to whether the problem of predicting structure from sequence is solved or not. Here, I argue that AlphaFold2 and its peers are currently limited by the fact that they predict only a single structure, instead of a structural distribution, and that this realization is crucial for the next generation of structure prediction algorithms. Nature Publishing Group US 2023-01-13 2023 /pmc/articles/PMC9839224/ /pubmed/36639584 http://dx.doi.org/10.1038/s41592-022-01760-4 Text en © Springer Nature America, Inc. 2023 This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.
spellingShingle Comment
Lane, Thomas J.
Protein structure prediction has reached the single-structure frontier
title Protein structure prediction has reached the single-structure frontier
title_full Protein structure prediction has reached the single-structure frontier
title_fullStr Protein structure prediction has reached the single-structure frontier
title_full_unstemmed Protein structure prediction has reached the single-structure frontier
title_short Protein structure prediction has reached the single-structure frontier
title_sort protein structure prediction has reached the single-structure frontier
topic Comment
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9839224/
https://www.ncbi.nlm.nih.gov/pubmed/36639584
http://dx.doi.org/10.1038/s41592-022-01760-4
work_keys_str_mv AT lanethomasj proteinstructurepredictionhasreachedthesinglestructurefrontier

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