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A conditional Smg6 mutant mouse model reveals circadian clock regulation through the nonsense-mediated mRNA decay pathway

Nonsense-mediated messenger RNA (mRNA) decay (NMD) has been intensively studied as a surveillance pathway that degrades erroneous transcripts arising from mutations or RNA processing errors. While additional roles in physiological control of mRNA stability have emerged, possible functions in mammali...

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Detalles Bibliográficos
Autores principales: Katsioudi, Georgia, Dreos, René, Arpa, Enes S., Gaspari, Sevasti, Liechti, Angelica, Sato, Miho, Gabriel, Christian H., Kramer, Achim, Brown, Steven A., Gatfield, David
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9839329/
https://www.ncbi.nlm.nih.gov/pubmed/36638184
http://dx.doi.org/10.1126/sciadv.ade2828