Progressive transformation of the HIV-1 reservoir cell profile over two decades of antiviral therapy

HIV-1 establishes a life-long reservoir of virally infected cells which cannot be eliminated by antiretroviral therapy (ART). Here, we demonstrate a markedly altered viral reservoir profile of long-term ART-treated individuals, characterized by large clones of intact proviruses preferentially integr...

Descripción completa

Detalles Bibliográficos
Autores principales: Lian, Xiaodong, Seiger, Kyra W., Parsons, Elizabeth M., Gao, Ce, Sun, Weiwei, Gladkov, Gregory T., Roseto, Isabelle C., Einkauf, Kevin B., Osborn, Matthew R., Chevalier, Joshua M., Jiang, Chenyang, Blackmer, Jane, Carrington, Mary, Rosenberg, Eric S., Lederman, Michael M., McMahon, Deborah K., Bosch, Ronald J., Jacobson, Jeffrey M., Gandhi, Rajesh T., Peluso, Michael J., Chun, Tae-Wook, Deeks, Steven G., Yu, Xu G., Lichterfeld, Mathias
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9839361/
https://www.ncbi.nlm.nih.gov/pubmed/36596305
http://dx.doi.org/10.1016/j.chom.2022.12.002

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9839361/
https://www.ncbi.nlm.nih.gov/pubmed/36596305
http://dx.doi.org/10.1016/j.chom.2022.12.002

Ejemplares similares