A genome-wide CRISPR screen identifies CALCOCO2 as a regulator of beta cell function influencing type 2 diabetes risk

Identification of the genes and processes mediating genetic association signals for complex diseases represents a major challenge. As many of the genetic signals for type 2 diabetes (T2D) exert their effects through pancreatic islet-cell dysfunction, we performed a genome-wide pooled CRISPR loss-of-...

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Detalles Bibliográficos
Autores principales: Rottner, Antje K., Ye, Yingying, Navarro-Guerrero, Elena, Rajesh, Varsha, Pollner, Alina, Bevacqua, Romina J., Yang, Jing, Spigelman, Aliya F., Baronio, Roberta, Bautista, Austin, Thomsen, Soren K., Lyon, James, Nawaz, Sameena, Smith, Nancy, Wesolowska-Andersen, Agata, Fox, Jocelyn E. Manning, Sun, Han, Kim, Seung K., Ebner, Daniel, MacDonald, Patrick E., Gloyn, Anna L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group US 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9839450/
https://www.ncbi.nlm.nih.gov/pubmed/36543916
http://dx.doi.org/10.1038/s41588-022-01261-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9839450/
https://www.ncbi.nlm.nih.gov/pubmed/36543916
http://dx.doi.org/10.1038/s41588-022-01261-2

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