Glucose and mannose analogs inhibit KSHV replication by blocking N‐glycosylation and inducing the unfolded protein response

Kaposi's sarcoma‐associated herpesvirus (KSHV) is the etiological agent for Kaposi's sarcoma (KS), an HIV/AIDS‐associated malignancy. Effective treatments against KS remain to be developed. The sugar analog 2‐deoxy‐ d‐glucose (2‐DG) is an anticancer agent that is well‐tolerated and safe in...

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Detalles Bibliográficos
Autores principales: Schlesinger, Mariana, McDonald, Christian, Ahuja, Anuj, Alvarez Canete, Carolina Alejandra, Nuñez del Prado, Zelmira, Naipauer, Julian, Lampidis, Theodore, Mesri, Enrique A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9839548/
https://www.ncbi.nlm.nih.gov/pubmed/36380418
http://dx.doi.org/10.1002/jmv.28314

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9839548/
https://www.ncbi.nlm.nih.gov/pubmed/36380418
http://dx.doi.org/10.1002/jmv.28314

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