Cargando…

Gut microbiome dysbiosis drives metabolic dysfunction in Familial dysautonomia

Familial dysautonomia (FD) is a rare genetic neurologic disorder caused by impaired neuronal development and progressive degeneration of both the peripheral and central nervous systems. FD is monogenic, with >99.4% of patients sharing an identical point mutation in the elongator acetyltransferase...

Descripción completa

Detalles Bibliográficos
Autores principales:	Cheney, Alexandra M., Costello, Stephanann M., Pinkham, Nicholas V., Waldum, Annie, Broadaway, Susan C., Cotrina-Vidal, Maria, Mergy, Marc, Tripet, Brian, Kominsky, Douglas J., Grifka-Walk, Heather M., Kaufmann, Horacio, Norcliffe-Kaufmann, Lucy, Peach, Jesse T., Bothner, Brian, Lefcort, Frances, Copié, Valérie, Walk, Seth T.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9839693/ https://www.ncbi.nlm.nih.gov/pubmed/36639365 http://dx.doi.org/10.1038/s41467-023-35787-8

Ejemplares similares

A Comprehensive NMR Analysis of Serum and Fecal Metabolites in Familial Dysautonomia Patients Reveals Significant Metabolic Perturbations
por: Costello, Stephanann M., et al.
Publicado: (2023)

Height, weight, and body mass index in patients with familial dysautonomia
por: Cotrina, Maria L., et al.
Publicado: (2023)

Amino Acid Trp: The Far Out Impacts of Host and Commensal Tryptophan Metabolism
por: Grifka-Walk, Heather M., et al.
Publicado: (2021)

Reduction of retinal ganglion cell death in mouse models of familial dysautonomia using AAV-mediated gene therapy and splicing modulators
por: Schultz, Anastasia, et al.
Publicado: (2023)

The familial dysautonomia disease gene IKBKAP is required in the developing and adult mouse central nervous system
por: Chaverra, Marta, et al.
Publicado: (2017)

Developmental Abnormalities, Blood Pressure Variability and Renal Disease In Riley Day Syndrome
por: Norcliffe-Kaufmann, Lucy, et al.
Publicado: (2011)

Characterization of Fatty Acids in Crenarchaeota by GC-MS and NMR
por: Hamerly, Timothy, et al.
Publicado: (2015)

Metabolic impact of polyphenol-rich aronia fruit juice mediated by inflammation status of gut microbiome donors in humanized mouse model
por: Wilson, Stephanie M. G., et al.
Publicado: (2023)

Loss of Elp1 disrupts trigeminal ganglion neurodevelopment in a model of familial dysautonomia
por: Leonard, Carrie E, et al.
Publicado: (2022)

Rethinking gut microbiome residency and the Enterobacteriaceae in healthy human adults
por: Martinson, Jonathan N. V., et al.
Publicado: (2019)

Temporal metabolic response yields a dynamic biosignature of inflammation
por: Peach, Jesse T., et al.
Publicado: (2021)

Loss of Ikbkap Causes Slow, Progressive Retinal Degeneration in a Mouse Model of Familial Dysautonomia
por: Ueki, Yumi, et al.
Publicado: (2016)

Disturbances in affective touch in hereditary sensory & autonomic neuropathy type III
por: Macefield, Vaughan G., et al.
Publicado: (2014)

Norepinephrine transporter defects lead to sympathetic hyperactivity in Familial Dysautonomia models
por: Wu, Hsueh-Fu, et al.
Publicado: (2022)

The Retina in Multiple System Atrophy: Systematic Review and Meta-Analysis
por: Mendoza-Santiesteban, Carlos E., et al.
Publicado: (2017)

Expanding the Genotypic Spectrum of Congenital Sensory and Autonomic Neuropathies Using Whole-Exome Sequencing
por: Palma, Jose-Alberto, et al.
Publicado: (2021)

Retina-specific loss of Ikbkap/Elp1 causes mitochondrial dysfunction that leads to selective retinal ganglion cell degeneration in a mouse model of familial dysautonomia
por: Ueki, Yumi, et al.
Publicado: (2018)

An ADAM17-Neutralizing Antibody Reduces Inflammation and Mortality While Increasing Viral Burden in a COVID-19 Mouse Model
por: Hedges, Jodi F., et al.
Publicado: (2022)

Vaginal biogenic amines: biomarkers of bacterial vaginosis or precursors to vaginal dysbiosis?
por: Nelson, Tiffanie M., et al.
Publicado: (2015)

Metabolic Implications of Using BioOrthogonal Non-Canonical Amino Acid Tagging (BONCAT) for Tracking Protein Synthesis
por: Steward, Katherine F., et al.
Publicado: (2020)

The Cortical Bone Metabolome of C57BL/6J Mice Is Sexually Dimorphic
por: Welhaven, Hope D., et al.
Publicado: (2022)

Safety and efficacy of ampreloxetine in symptomatic neurogenic orthostatic hypotension: a phase 2 trial
por: Kaufmann, Horacio, et al.
Publicado: (2021)

Distinct Metabolic States Are Observed in Hypoglycemia Induced in Mice by Ricin Toxin or by Fasting
por: Kempa, Jacob, et al.
Publicado: (2022)

Is 'happy hypoxia' in COVID-19 a disorder of autonomic interoception? A hypothesis
por: González-Duarte, Alejandra, et al.
Publicado: (2020)

Introducing the ArsR-Regulated Arsenic Stimulon
por: Rawle, Rachel, et al.
Publicado: (2021)

Dysautonomia in two littermate kittens
por: Černá, Petra, et al.
Publicado: (2023)

Dysautonomia in Alzheimer's Disease
por: Tulbă, Delia, et al.
Publicado: (2020)

COVID-19 Dysautonomia
por: Goodman, Brent P., et al.
Publicado: (2021)

Metabolic Responses to Arsenite Exposure Regulated through Histidine Kinases PhoR and AioS in Agrobacterium tumefaciens 5A
por: Rawle, Rachel A., et al.
Publicado: (2020)

Longitudinal analysis of the Five Sisters hot springs in Yellowstone National Park reveals a dynamic thermoalkaline environment
por: Peach, Jesse T., et al.
Publicado: (2022)

Dysautonomia, fibromyalgia and reflex dystrophy
por: Eisinger, Jean
Publicado: (2007)

Familial Dysautonomia: Mechanisms and Models
por: Dietrich, Paula, et al.
Publicado: (2016)

Dysautonomia: an Explanation for the Medically Unexplained?
por: Chandrasekaram, Senthil, et al.
Publicado: (2016)

COVID-19-Associated Dysautonomia
por: Suresh, Krithika, et al.
Publicado: (2021)

Dysautonomia in Amyotrophic Lateral Sclerosis
por: Oprisan, Alexandra L., et al.
Publicado: (2023)

The gut microbiome is required for full protection against acute arsenic toxicity in mouse models
por: Coryell, Michael, et al.
Publicado: (2018)

Detection and elimination of a novel non-toxigenic Clostridioides difficile strain from the microbiota of a mouse colony
por: Maslanka, Jeffrey R., et al.
Publicado: (2020)

Dysautonomia in Narcolepsy: Evidence by Questionnaire Assessment
por: Klein, Gilles, et al.
Publicado: (2014)

Cyanosis With Dysautonomia Mimics Raynaud Disease
por: Soloway, Alyxandra Morgan, et al.
Publicado: (2020)

Genetic testing for autonomic dysfunction or dysautonomias
por: Maltese, Paolo Enrico, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_agfc80vpmbdjnuja1hoaf7h8fo