Cryo-EM structures of orphan GPR21 signaling complexes

GPR21 is a class-A orphan G protein-coupled receptor (GPCR) and a potential therapeutic target for type 2 diabetes and other metabolic disorders. This receptor shows high basal activity in coupling to multiple G proteins in the absence of any known endogenous agonist or synthetic ligand. Here, we pr...

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Detalles Bibliográficos
Autores principales: Lin, Xi, Chen, Bo, Wu, Yiran, Han, Yingqi, Qi, Ao, Wang, Junyan, Yang, Zhao, Wei, Xiaohu, Zhao, Tingting, Wu, Lijie, Xie, Xin, Sun, Jinpeng, Zheng, Jie, Zhao, Suwen, Xu, Fei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9839698/
https://www.ncbi.nlm.nih.gov/pubmed/36639690
http://dx.doi.org/10.1038/s41467-023-35882-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9839698/
https://www.ncbi.nlm.nih.gov/pubmed/36639690
http://dx.doi.org/10.1038/s41467-023-35882-w

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