Multivariate chemogenomic screening prioritizes new macrofilaricidal leads

Development of direct acting macrofilaricides for the treatment of human filariases is hampered by limitations in screening throughput imposed by the parasite life cycle. In vitro adult screens typically assess single phenotypes without prior enrichment for chemicals with antifilarial potential. We...

Descripción completa

Detalles Bibliográficos
Autores principales: Wheeler, Nicolas J., Ryan, Kaetlyn T., Gallo, Kendra J., Henthorn, Clair R., Ericksen, Spencer S., Chan, John D., Zamanian, Mostafa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9839782/
https://www.ncbi.nlm.nih.gov/pubmed/36639423
http://dx.doi.org/10.1038/s42003-023-04435-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9839782/
https://www.ncbi.nlm.nih.gov/pubmed/36639423
http://dx.doi.org/10.1038/s42003-023-04435-8

Ejemplares similares