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A KO mouse model for the lncRNA Lhx1os produces motor neuron alterations and locomotor impairment
Here, we describe a conserved motor neuron-specific long non-coding RNA, Lhx1os, whose knockout in mice produces motor impairment and postnatal reduction of mature motor neurons (MNs). The ER stress-response pathway result specifically altered with the downregulation of factors involved in the unfol...
Autores principales: | , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9840152/ https://www.ncbi.nlm.nih.gov/pubmed/36647387 http://dx.doi.org/10.1016/j.isci.2022.105891 |