A KO mouse model for the lncRNA Lhx1os produces motor neuron alterations and locomotor impairment

Here, we describe a conserved motor neuron-specific long non-coding RNA, Lhx1os, whose knockout in mice produces motor impairment and postnatal reduction of mature motor neurons (MNs). The ER stress-response pathway result specifically altered with the downregulation of factors involved in the unfol...

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Detalles Bibliográficos
Autores principales: Pellegrini, Flaminia, Padovano, Vittorio, Biscarini, Silvia, Santini, Tiziana, Setti, Adriano, Galfrè, Silvia Giulia, Silenzi, Valentina, Vitiello, Erika, Mariani, Davide, Nicoletti, Carmine, Torromino, Giulia, De Leonibus, Elvira, Martone, Julie, Bozzoni, Irene
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9840152/
https://www.ncbi.nlm.nih.gov/pubmed/36647387
http://dx.doi.org/10.1016/j.isci.2022.105891

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