Evaluating and implementing block jackknife resampling Mendelian randomization to mitigate bias induced by overlapping samples

Participant overlap can induce overfitting bias into Mendelian randomization (MR) and polygenic risk score (PRS) studies. Here, we evaluated a block jackknife resampling framework for genome-wide association studies (GWAS) and PRS construction to mitigate overfitting bias in MR analyses and implemen...

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Detalles Bibliográficos
Autores principales: Fang, Si, Hemani, Gibran, Richardson, Tom G, Gaunt, Tom R, Davey Smith, George
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9840213/
https://www.ncbi.nlm.nih.gov/pubmed/35932451
http://dx.doi.org/10.1093/hmg/ddac186

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9840213/
https://www.ncbi.nlm.nih.gov/pubmed/35932451
http://dx.doi.org/10.1093/hmg/ddac186

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