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Evaluating and implementing block jackknife resampling Mendelian randomization to mitigate bias induced by overlapping samples
Participant overlap can induce overfitting bias into Mendelian randomization (MR) and polygenic risk score (PRS) studies. Here, we evaluated a block jackknife resampling framework for genome-wide association studies (GWAS) and PRS construction to mitigate overfitting bias in MR analyses and implemen...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Oxford University Press
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9840213/ https://www.ncbi.nlm.nih.gov/pubmed/35932451 http://dx.doi.org/10.1093/hmg/ddac186 |