p16INK4A-dependent senescence in the bone marrow niche drives age-related metabolic changes of hematopoietic progenitors

Rapid and effective leukocyte response to infection is a fundamental function of the bone marrow (BM). However, with increasing age, this response becomes impaired, resulting in an increased burden of infectious diseases. Here, we investigate how aging changes the metabolism and function of hematopo...

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Detalles Bibliográficos
Autores principales: Hellmich, Charlotte, Wojtowicz, Edyta, Moore, Jamie A., Mistry, Jayna J., Jibril, Aisha, Johnson, Benjamin B., Smith, James G. W., Beraza, Naiara, Bowles, Kristian M., Rushworth, Stuart A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The American Society of Hematology 2022
Materias:
Hematopoiesis and Stem Cells
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9840237/
https://www.ncbi.nlm.nih.gov/pubmed/35622970
http://dx.doi.org/10.1182/bloodadvances.2022007033

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9840237/
https://www.ncbi.nlm.nih.gov/pubmed/35622970
http://dx.doi.org/10.1182/bloodadvances.2022007033

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