A novel human tau knock-in mouse model reveals interaction of Abeta and human tau under progressing cerebral amyloidosis in 5xFAD mice

BACKGROUND: Hyperphosphorylation and intraneuronal aggregation of the microtubule-associated protein tau is a major pathological hallmark of Alzheimer’s disease (AD) brain. Of special interest is the effect of cerebral amyloid beta deposition, the second main hallmark of AD, on human tau pathology....

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Detalles Bibliográficos
Autores principales: Barendrecht, Susan, Schreurs, An, Geissler, Stefanie, Sabanov, Victor, Ilse, Victoria, Rieckmann, Vera, Eichentopf, Rico, Künemund, Anja, Hietel, Benjamin, Wussow, Sebastian, Hoffmann, Katrin, Körber-Ferl, Kerstin, Pandey, Ravi, Carter, Gregory W., Demuth, Hans-Ulrich, Holzer, Max, Roßner, Steffen, Schilling, Stephan, Preuss, Christoph, Balschun, Detlef, Cynis, Holger
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9840277/
https://www.ncbi.nlm.nih.gov/pubmed/36641439
http://dx.doi.org/10.1186/s13195-022-01144-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9840277/
https://www.ncbi.nlm.nih.gov/pubmed/36641439
http://dx.doi.org/10.1186/s13195-022-01144-y

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