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Tyrosine phosphatase STEP(61) in human dementia and in animal models with amyloid and tau pathology

Synaptic degeneration is a precursor of synaptic and neuronal loss in neurodegenerative diseases such as Alzheimer’s disease (AD) and frontotemporal dementia with tau pathology (FTD-tau), a group of primary tauopathies. A critical role in this degenerative process is assumed by enzymes such as the k...

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Detalles Bibliográficos
Autores principales: Taylor, Deonne, Kneynsberg, Andrew, van Roijen, Marloes, Götz, Jürgen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9840288/
https://www.ncbi.nlm.nih.gov/pubmed/36639708
http://dx.doi.org/10.1186/s13041-023-00994-3