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Lineage tracing reveals fate bias and transcriptional memory in human B cells

We combined single-cell transcriptomics and lineage tracing to understand fate choice in human B cells. Using the antibody sequences of B cells, we tracked clones during in vitro differentiation. Clonal analysis revealed a subset of IgM+ B cells which were more proliferative than other B-cell types....

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Detalles Bibliográficos
Autores principales: Swift, Michael, Horns, Felix, Quake, Stephen R
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Life Science Alliance LLC 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9840405/
https://www.ncbi.nlm.nih.gov/pubmed/36639222
http://dx.doi.org/10.26508/lsa.202201792