The Successful Implementation of a Modified Pediatric Acute Lymphoblastic Leukemia Protocol to Treat an Elderly Patient With T-cell Lymphoblastic Leukemia: A Case Report
Acute lymphoblastic leukemia (ALL) is a group of hematological malignancies most commonly seen in pediatrics. The disease process localizes in lymphoid organs, the central nervous system, the mediastinum, and bone marrow (BM). The clinical features of T-cell acute lymphoblastic leukemia (T-ALL) in a...
Autores principales: | , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Cureus
2023
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9840415/ https://www.ncbi.nlm.nih.gov/pubmed/36655154 http://dx.doi.org/10.7759/cureus.33729 |
_version_ | 1784869638060900352 |
---|---|
author | Motabi, Ibraheem H Alsaif, Yara A Bin Shuayl, Mohammed K Farwana, Faisal M Alhassan, Abdulaziz T Alsaif, Faisal A |
author_facet | Motabi, Ibraheem H Alsaif, Yara A Bin Shuayl, Mohammed K Farwana, Faisal M Alhassan, Abdulaziz T Alsaif, Faisal A |
author_sort | Motabi, Ibraheem H |
collection | PubMed |
description | Acute lymphoblastic leukemia (ALL) is a group of hematological malignancies most commonly seen in pediatrics. The disease process localizes in lymphoid organs, the central nervous system, the mediastinum, and bone marrow (BM). The clinical features of T-cell acute lymphoblastic leukemia (T-ALL) in adults include evidence of generalized lymphadenopathy, hepatosplenomegaly, immunosuppression, and hypercalcemia. There is limited research on the efficacy of using modified pediatric treatment regimens in the elderly over the age of 60 with ALL; this case report aims to illustrate the successful treatment of a 67-year-old male patient diagnosed with T-ALL, using a modified Children's Oncology Group (COG) protocol. Through this, it has been shown to be an effective, safe, and efficacious treatment option for our patient. |
format | Online Article Text |
id | pubmed-9840415 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Cureus |
record_format | MEDLINE/PubMed |
spelling | pubmed-98404152023-01-17 The Successful Implementation of a Modified Pediatric Acute Lymphoblastic Leukemia Protocol to Treat an Elderly Patient With T-cell Lymphoblastic Leukemia: A Case Report Motabi, Ibraheem H Alsaif, Yara A Bin Shuayl, Mohammed K Farwana, Faisal M Alhassan, Abdulaziz T Alsaif, Faisal A Cureus Internal Medicine Acute lymphoblastic leukemia (ALL) is a group of hematological malignancies most commonly seen in pediatrics. The disease process localizes in lymphoid organs, the central nervous system, the mediastinum, and bone marrow (BM). The clinical features of T-cell acute lymphoblastic leukemia (T-ALL) in adults include evidence of generalized lymphadenopathy, hepatosplenomegaly, immunosuppression, and hypercalcemia. There is limited research on the efficacy of using modified pediatric treatment regimens in the elderly over the age of 60 with ALL; this case report aims to illustrate the successful treatment of a 67-year-old male patient diagnosed with T-ALL, using a modified Children's Oncology Group (COG) protocol. Through this, it has been shown to be an effective, safe, and efficacious treatment option for our patient. Cureus 2023-01-13 /pmc/articles/PMC9840415/ /pubmed/36655154 http://dx.doi.org/10.7759/cureus.33729 Text en Copyright © 2023, Motabi et al. https://creativecommons.org/licenses/by/3.0/This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Internal Medicine Motabi, Ibraheem H Alsaif, Yara A Bin Shuayl, Mohammed K Farwana, Faisal M Alhassan, Abdulaziz T Alsaif, Faisal A The Successful Implementation of a Modified Pediatric Acute Lymphoblastic Leukemia Protocol to Treat an Elderly Patient With T-cell Lymphoblastic Leukemia: A Case Report |
title | The Successful Implementation of a Modified Pediatric Acute Lymphoblastic Leukemia Protocol to Treat an Elderly Patient With T-cell Lymphoblastic Leukemia: A Case Report |
title_full | The Successful Implementation of a Modified Pediatric Acute Lymphoblastic Leukemia Protocol to Treat an Elderly Patient With T-cell Lymphoblastic Leukemia: A Case Report |
title_fullStr | The Successful Implementation of a Modified Pediatric Acute Lymphoblastic Leukemia Protocol to Treat an Elderly Patient With T-cell Lymphoblastic Leukemia: A Case Report |
title_full_unstemmed | The Successful Implementation of a Modified Pediatric Acute Lymphoblastic Leukemia Protocol to Treat an Elderly Patient With T-cell Lymphoblastic Leukemia: A Case Report |
title_short | The Successful Implementation of a Modified Pediatric Acute Lymphoblastic Leukemia Protocol to Treat an Elderly Patient With T-cell Lymphoblastic Leukemia: A Case Report |
title_sort | successful implementation of a modified pediatric acute lymphoblastic leukemia protocol to treat an elderly patient with t-cell lymphoblastic leukemia: a case report |
topic | Internal Medicine |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9840415/ https://www.ncbi.nlm.nih.gov/pubmed/36655154 http://dx.doi.org/10.7759/cureus.33729 |
work_keys_str_mv | AT motabiibraheemh thesuccessfulimplementationofamodifiedpediatricacutelymphoblasticleukemiaprotocoltotreatanelderlypatientwithtcelllymphoblasticleukemiaacasereport AT alsaifyaraa thesuccessfulimplementationofamodifiedpediatricacutelymphoblasticleukemiaprotocoltotreatanelderlypatientwithtcelllymphoblasticleukemiaacasereport AT binshuaylmohammedk thesuccessfulimplementationofamodifiedpediatricacutelymphoblasticleukemiaprotocoltotreatanelderlypatientwithtcelllymphoblasticleukemiaacasereport AT farwanafaisalm thesuccessfulimplementationofamodifiedpediatricacutelymphoblasticleukemiaprotocoltotreatanelderlypatientwithtcelllymphoblasticleukemiaacasereport AT alhassanabdulazizt thesuccessfulimplementationofamodifiedpediatricacutelymphoblasticleukemiaprotocoltotreatanelderlypatientwithtcelllymphoblasticleukemiaacasereport AT alsaiffaisala thesuccessfulimplementationofamodifiedpediatricacutelymphoblasticleukemiaprotocoltotreatanelderlypatientwithtcelllymphoblasticleukemiaacasereport AT motabiibraheemh successfulimplementationofamodifiedpediatricacutelymphoblasticleukemiaprotocoltotreatanelderlypatientwithtcelllymphoblasticleukemiaacasereport AT alsaifyaraa successfulimplementationofamodifiedpediatricacutelymphoblasticleukemiaprotocoltotreatanelderlypatientwithtcelllymphoblasticleukemiaacasereport AT binshuaylmohammedk successfulimplementationofamodifiedpediatricacutelymphoblasticleukemiaprotocoltotreatanelderlypatientwithtcelllymphoblasticleukemiaacasereport AT farwanafaisalm successfulimplementationofamodifiedpediatricacutelymphoblasticleukemiaprotocoltotreatanelderlypatientwithtcelllymphoblasticleukemiaacasereport AT alhassanabdulazizt successfulimplementationofamodifiedpediatricacutelymphoblasticleukemiaprotocoltotreatanelderlypatientwithtcelllymphoblasticleukemiaacasereport AT alsaiffaisala successfulimplementationofamodifiedpediatricacutelymphoblasticleukemiaprotocoltotreatanelderlypatientwithtcelllymphoblasticleukemiaacasereport |