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Fmr1-KO mice failure to detect object novelty associates with a post-test decrease of structural and synaptic plasticity upstream of the hippocampus

Mice with deletion of the FMR1 gene show episodic memory impairments and exhibit dendritic spines and synaptic plasticity defects prevalently identified in non-training conditions. Based on evidence that synaptic changes associated with normal or abnormal memory emerge when mice are cognitively chal...

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Detalles Bibliográficos
Autores principales: Borreca, Antonella, De Luca, Mariassunta, Ferrante, Antonella, Boussadia, Zaira, Pignataro, Annabella, Martire, Alberto, Ammassari-Teule, Martine
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9840621/
https://www.ncbi.nlm.nih.gov/pubmed/36641518
http://dx.doi.org/10.1038/s41598-023-27991-9