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Inhibition of c-Jun in AgRP neurons increases stress-induced anxiety and colitis susceptibility

Psychiatric disorders, such as anxiety, are associated with inflammatory bowel disease (IBD), however, the neural mechanisms regulating this comorbidity are unknown. Here, we show that hypothalamic agouti-related protein (AgRP) neuronal activity is suppressed under chronic restraint stress (CRS), a...

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Detalles Bibliográficos
Autores principales: Jiao, Fuxin, Hu, Xiaoming, Yin, Hanrui, Yuan, Feixiang, Zhou, Ziheng, Wu, Wei, Chen, Shanghai, Liu, Zhanju, Guo, Feifan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9840628/
https://www.ncbi.nlm.nih.gov/pubmed/36641530
http://dx.doi.org/10.1038/s42003-023-04425-w