Systemic administration of novel engineered AAV capsids facilitates enhanced transgene expression in the macaque CNS

BACKGROUND: Adeno-associated virus (AAV) vectors are a promising vehicle for noninvasive gene delivery to the central nervous system via intravenous infusion. However, naturally occurring serotypes have a limited ability to transduce the brain, and translating engineered capsids from mice to nonhuma...

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Detalles Bibliográficos
Autores principales: Stanton, Alexandra C., Lagerborg, Kim A., Tellez, Liana, Krunnfusz, Allison, King, Emily M., Ye, Simon, Solomon, Isaac H., Tabebordbar, Mohammadsharif, Sabeti, Pardis C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9840684/
https://www.ncbi.nlm.nih.gov/pubmed/36417917
http://dx.doi.org/10.1016/j.medj.2022.11.002

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9840684/
https://www.ncbi.nlm.nih.gov/pubmed/36417917
http://dx.doi.org/10.1016/j.medj.2022.11.002

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