ARID1A loss in pancreas leads to islet developmental defect and metabolic disturbance

ARID1A is a tumor suppressor gene mutated in 7–10% of pancreatic cancer patients. However, its function in pancreas development and endocrine regulation is unclear. We generated mice that lack Arid1a expression in the pancreas. Our results showed that deletion of the Arid1a gene in mice caused a red...

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Detalles Bibliográficos
Autores principales: Kuo, Tzu-Lei, Cheng, Kuang-Hung, Chen, Li-Tzong, Hung, Wen-Chun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9840936/
https://www.ncbi.nlm.nih.gov/pubmed/36654862
http://dx.doi.org/10.1016/j.isci.2022.105881

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9840936/
https://www.ncbi.nlm.nih.gov/pubmed/36654862
http://dx.doi.org/10.1016/j.isci.2022.105881

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