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ARID1A loss in pancreas leads to islet developmental defect and metabolic disturbance
ARID1A is a tumor suppressor gene mutated in 7–10% of pancreatic cancer patients. However, its function in pancreas development and endocrine regulation is unclear. We generated mice that lack Arid1a expression in the pancreas. Our results showed that deletion of the Arid1a gene in mice caused a red...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Elsevier
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9840936/ https://www.ncbi.nlm.nih.gov/pubmed/36654862 http://dx.doi.org/10.1016/j.isci.2022.105881 |