Quality by Design in Downstream Process Development of Romiplostim

BACKGROUND: Downstream processing of therapeutic recombinant proteins expressed as the IBs in E. coli is quite challenging. This study aimed to use the QbD approach for developing the multi-step downstream process of a structurally complex therapeutic Fc-Peptide fusion protein, romiplostim. METHODS:...

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Detalles Bibliográficos
Autores principales: Pouri, Saeedeh, Torkashvand, Fatemeh, Aghamirza Moghim, Hooman, Fard-Esfahani, Pezhman, Golkar, Majid, Vaziri, Behrouz
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Pasteur Institute of Iran 2022
Materias:
Full Length
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9841220/
https://www.ncbi.nlm.nih.gov/pubmed/36439274
http://dx.doi.org/10.52547/ibj.3790

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9841220/
https://www.ncbi.nlm.nih.gov/pubmed/36439274
http://dx.doi.org/10.52547/ibj.3790

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