Design and conduct considerations for studies in patients with hepatic impairment

Despite the liver being the primary site for clearance of xenobiotics utilizing a myriad of mechanisms ranging from cytochrome P450 enzyme pathways, glucuronidation, and biliary excretion, there is a dearth of information available as to how the severity of hepatic impairment (HI) can alter drug abs...

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Detalles Bibliográficos
Autores principales: Ravenstijn, Paulien, Chetty, Manoranjenni, Manchandani, Pooja, Elmeliegy, Mohamed, Qosa, Hisham, Younis, Islam
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
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Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9841300/
https://www.ncbi.nlm.nih.gov/pubmed/36176049
http://dx.doi.org/10.1111/cts.13428

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9841300/
https://www.ncbi.nlm.nih.gov/pubmed/36176049
http://dx.doi.org/10.1111/cts.13428

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