The disulfide catalyst QSOX1 maintains the colon mucosal barrier by regulating Golgi glycosyltransferases

Mucus is made of enormous mucin glycoproteins that polymerize by disulfide crosslinking in the Golgi apparatus. QSOX1 is a catalyst of disulfide bond formation localized to the Golgi. Both QSOX1 and mucins are highly expressed in goblet cells of mucosal tissues, leading to the hypothesis that QSOX1...

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Detalles Bibliográficos
Autores principales: Ilani, Tal, Reznik, Nava, Yeshaya, Noa, Feldman, Tal, Vilela, Patrick, Lansky, Zipora, Javitt, Gabriel, Shemesh, Michal, Brenner, Ori, Elkis, Yoav, Varsano, Neta, Jaramillo, Ana M, Evans, Christopher M, Fass, Deborah
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9841341/
https://www.ncbi.nlm.nih.gov/pubmed/36245281
http://dx.doi.org/10.15252/embj.2022111869

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9841341/
https://www.ncbi.nlm.nih.gov/pubmed/36245281
http://dx.doi.org/10.15252/embj.2022111869

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