Targeting succinate metabolism to decrease brain injury upon mechanical thrombectomy treatment of ischemic stroke

Current treatments for acute ischemic stroke aim to reinstate a normal perfusion in the ischemic territory but can also cause significant ischemia-reperfusion (IR) injury. Previous data in experimental models of stroke show that ischemia leads to the accumulation of succinate, and, upon reperfusion,...

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Detalles Bibliográficos
Autores principales: Mottahedin, Amin, Prag, Hiran A., Dannhorn, Andreas, Mair, Richard, Schmidt, Christina, Yang, Ming, Sorby-Adams, Annabel, Lee, Jordan J., Burger, Nils, Kulaveerasingam, Duvaraka, Huang, Margaret M., Pluchino, Stefano, Peruzzotti-Jametti, Luca, Goodwin, Richard, Frezza, Christian, Murphy, Michael P., Krieg, Thomas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9841348/
https://www.ncbi.nlm.nih.gov/pubmed/36630820
http://dx.doi.org/10.1016/j.redox.2023.102600

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9841348/
https://www.ncbi.nlm.nih.gov/pubmed/36630820
http://dx.doi.org/10.1016/j.redox.2023.102600

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