The interaction between transport-segment DNA and topoisomerase IA—crystal structure of MtbTOP1 in complex with both G- and T-segments

Each catalytic cycle of type IA topoisomerases has been proposed to comprise multistep reactions. The capture of the transport-segment DNA (T-segment) into the central cavity of the N-terminal toroidal structure is an important action, which is preceded by transient gate-segment (G-segment) cleavage...

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Detalles Bibliográficos
Autores principales: Ferdous, Shomita, Dasgupta, Tumpa, Annamalai, Thirunavukkarasu, Tan, Kemin, Tse-Dinh, Yuk-Ching
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
Materias:
Nucleic Acid Enzymes
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9841409/
https://www.ncbi.nlm.nih.gov/pubmed/36583363
http://dx.doi.org/10.1093/nar/gkac1205

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9841409/
https://www.ncbi.nlm.nih.gov/pubmed/36583363
http://dx.doi.org/10.1093/nar/gkac1205

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